The Guilt Trip

Seth Rogen

Andy Brewster

Barbra Streisand

Joyce Brewster

Yvonne Strahovski

Jessica

Colin Hanks

Rob

Brett Cullen

Ben

Adam Scott

Andrew Margolis Jr.

Ari Graynor

Joyce Margolis

Kathy Najimy

Gayle

Danny Pudi

Sanjay

Casey Wilson

Amanda

Dale Dickey

Tammy

Brandon Keener

Ryan Mcfee

Robert Curtis Brown

Bob Ferguson

Nora Dunn

Amy

Miriam Margolyes

Anita

Rose Abdoo

Diana

Analeis Anderson

Moonlight

Gabrielle Gumbs

Stripper

Rick Gonzalez

Mark

Worth Howe

Bob

Vicki Goldsmith

Young Joyce

Constance Esposito

HSN Executive

Creed Bratton

Suitor

Jeff Kober

Jimmy

Tom Virtue

Mature Singles Man

John Funk

K-Mart Executive

Julene Renee

K-Mart Receptionist (as Julene Renee-Preciado)

Matthew Levinson

Toddler Andy

Vivian Vanderwerd

Mature Singles Woman

Zabryna Guevara

K-Mart Executive

Michael Cassidy

Fake Andy (uncredited)